Clare M. Waterman

This study shows that cholesterol metabolism remodeling in melanoma progression alters nuclear membrane mechanics, increasing tension and vulnerability to rupture during cellular confinement.

The paper investigates how CD44 and Ezrin restrict EGF receptor mobility to create a spatial signaling gradient that stabilizes bleb-based migration in non-adhesive environments.

This study shows that increased LBR cholesterol synthase activity in metastatic melanoma leads to nuclear envelope fragility by accumulating cholesterol, promoting NE rupture during cell migration.

This study shows that mechanical forces during epithelialization in pluripotent stem cells drive nuclear changes that prime neuroectodermal lineage commitment.