Shonna M. McBride

This study shows that proline fermentation via the proline reductase pathway supports C. difficile spore maturation and that excess proline represses sporulation through PrdR regulation.

This study identifies KipOTIA in C. difficile as a detoxifying enzyme that converts 5-oxoproline into a nutrient, supporting bacterial growth.

This study identifies SmrR and SmrT as pH-responsive genes in C. difficile that regulate sporulation, toxin production, and antimicrobial resistance.

This study identifies and characterizes a β-lactamase, BlaD, in C. difficile that contributes to β-lactam resistance, showing its regulation by BlaRI and the role of a co-transcribed lipoprotein, BlaX.