Conor P O'Byrne

The paper investigates how altered start codon usage modulates the general stress response and virulence in Listeria monocytogenes by analyzing mutations in regulatory genes and genome-wide start codon usage patterns.

This study identifies GadR, a novel RofA-family transcriptional regulator in L. monocytogenes, which controls acid resistance by regulating the gadT2D2 operon and is linked to strain-specific survival differences in acidic environments.

This study shows that Listeria monocytogenes evolves to lose SigB or Agr function under different temperatures, increasing competitive fitness in specific conditions.

This study identifies the role of the stressosome in acid stress signaling and σB activation in Listeria monocytogenes, showing phosphorylation of RsbS and RsbR1 is essential for this process.