Vandana Kalia

The paper investigates the role of TLR signaling in Leigh syndrome using a mouse model and finds that MyD88 deficiency modestly improves disease outcomes, while enrofloxacin treatment accelerates disease progression.

This study investigates the effects of hypoxia and immune interventions in a mouse model of Leigh syndrome, showing that immune cell depletion suppresses disease and hypoxia cessation accelerates disease onset.

This study investigates how SARS-CoV-2 S1 protein induces systemic immune responses and long-term anxiety-like behaviors in mice.

This study presents a CRISPR-Cas9-based method to delete genes in primary murine CD8 T cells to assess their functional roles in immune responses and cancer.

This study shows miR-17~92 promotes T cell proliferation and effector differentiation by regulating metabolic pathways like glycolysis and mTOR activation in viral antigen-specific CD4 and CD8 T cells.

This study identifies Treg-mediated suppression of CD4 T cells and inflammatory myeloid cells as critical for metabolic remodeling of CD8 T cells during the effector-to-memory transition.

This study examines how a Treg-selective IL-2 mutein affects influenza-specific T cell responses, showing opposing effects based on administration timing.

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

This paper develops injectable hydrogels that enable controlled, extended release of protein therapeutics through hydrolysable linkers, demonstrating efficacy in a mouse melanoma model.