Florian Eberhardt

The paper investigates whether cable theory assumptions hold in dendritic spines by simulating ion concentrations and membrane potential using PNP equations, finding electroneutrality is valid and cable parameters are constant.

The paper presents a generalized cable equation that accounts for ion concentration changes in dendritic spines, showing that ion diffusion affects voltage depolarization during synaptic input.

The paper quantifies how the actin cytoskeleton in dendritic spines affects ion transport by modifying diffusion and permittivity using homogenization of PNP equations.