Angela Giangrande

This study shows that altering the MYC/MAX ratio in Drosophila eye progenitors changes cell fate by rewiring HOX gene expression and reprogramming progenitor identity.

The paper identifies NimA as a glial-specific protein in Drosophila that regulates cell adhesion at the blood-brain barrier, essential for BBB integrity and neural development.

This study shows that Drosophila larval macrophages reprogram their metabolism in response to high sugar diets, with mixed effects on growth, where lipogenic shifts promote growth but are insufficient to counteract other metabolic changes.

This study shows that reducing Glide/Gcm in Drosophila hemocytes increases inflammation from Toll pathway activation and reveals a role for neurotransmitter receptors in the inflammatory response.

The paper identifies cell- and stage-specific transcriptional signatures in Drosophila neurons, glia, and hemocytes, revealing that developmental stage significantly influences gene expression patterns.

This study identifies a conserved anti-inflammatory transcriptional cascade involving Gcm in flies and humans, showing its role in modulating inflammation across species.

The paper uses bulk and single-cell RNA sequencing to study Drosophila hemocyte heterogeneity across developmental stages and immune challenges, identifying novel cell types and functional states.

The paper shows that hypoxia in Drosophila trh mutants causes glial-induced synaptic remodeling through HIF-1/Sima and Wg signaling, maintaining synaptic transmission for larval locomotion.