Andrew A. Pieper

This study shows that aging-related changes in cysteine posttranslational modifications alter protein phase separation, leading to aggregation and neurodegeneration.

This study develops a single-cell digital twin framework to identify drug targets and repurposable medicines in Alzheimer's disease using single-nuclei RNA-seq and ATAC-seq data.

The paper identifies cell-type-specific metabolic regulators in Alzheimer's disease using scFUMES, revealing key interactions that reduce pathological tau species.

This paper identifies a novel non-enzymatic role for BVRA in modulating Nrf2 signaling, revealing its importance in neuroprotection and potential as a therapeutic target for neurodegenerative diseases.

This study shows that inhibiting 15-PGDH improves hematopoietic stem cell function and recovery in aged mice without affecting normal blood production.

This study integrates multi-omics data using network medicine to identify potential drug targets and repurposable treatments for ALS.

This study identifies GPCR targets of gut microbiota metabolites in Alzheimer's disease using multi-omics and machine learning.

This study develops an in vivo method to monitor axonal activity over time in mice and shows that P7C3-A20 reduces but does not eliminate axonal dysfunction after brain injury.

This study shows that anti-inflammatory therapies protect spiral ganglion neurons after aminoglycoside-induced hair cell loss by reducing macrophage activation and neuroinflammation.

This study links SARS-CoV-2 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment through network-based genomics analysis.

AlzGPS integrates multi-omics data and networks to identify repurposable drugs for Alzheimer's disease.

This study characterizes two models of post-traumatic headache, showing distinct tactile hypersensitivity profiles and highlighting the role of CGRP in persistent hypersensitivity.