Sitapriya Moorthi

This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.

This paper identifies SGMS1 as a novel target of the GATA1/TAL1 transcriptional complex and shows its role in G2/M cell cycle regulation, suggesting a potential therapeutic strategy for M6 AML.

This study shows that USP9X stabilizes RIT1 protein and that its depletion reduces RIT1 abundance and sensitizes cells to EGFR inhibitors.

The paper compares somatic mutations and aneuploidy in lung adenocarcinomas from never-smokers and smokers, finding that mutations, not copy number changes, distinguish the two groups.