The paper presents the cryo-EM structure of a β1-adrenoceptor-AmpC β-lactamase fusion protein in the inactive state, revealing conformational dynamics and potential for GPCR structure elucidation.

2 citations

protein structureexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 15, 2026

Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase

Weaam I Mohamed, Julius Rabl, Bilal Muhammad Qureshi…·Matthias Peter

This study identifies molecular determinants that guide DCAF specificity for CUL4B in the CRL4B E3 ubiquitin ligase complex through structural and biochemical analyses.

DOI 10.64898/2026.03.13.711546

humanstructural biology

𝕏 PostBluesky

ImmunologyNature Cell BiologyPeer-reviewedMar 13, 2026

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

Eric J. Aird, Julius Rabl, Tabea Knuesel…·Jacob E. Corn

The paper identifies SP110 as a negative regulator of type 1 interferon-driven cell death by counteracting SP100's toxic filament formation through CARD domain interactions.

5 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Molecular BiologybioRxivPreprintApr 3, 2023

Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding ofproteins with alpha helical domains

Arka Banerjee, Meriç Ataman, Maciej Jerzy Smialek…·Mihaela Zavolan

This study identifies RPL39L as an efficiency factor in cotranslational folding of alpha helical proteins by analyzing its expression, ribosome structure, and impact on translation dynamics.

1 citation

humanmouse

𝕏 PostBluesky