Zeyu Chen

This study identifies a novel antifungal compound targeting ALS, validated through genome mining, biochemical assays, and a mouse model of invasive aspergillosis.

This study identifies how histone modifications regulate gene expression in memory and exhausted CD8 T cells, revealing distinct epigenetic programs between these cell types.

The paper identifies four immunomodulatory programs in glioma-associated myeloid cells using scRNA-seq and shows they are driven by microenvironmental cues and therapies, not cell type or mutation status.

The paper develops a tool for continuous, long-range, targeted diversification of endogenous mammalian genomes and uses it to explore the function of genetic variants in both coding and non-coding regions.

This study identifies an AhR-Ovol1-Id1 regulatory axis in keratinocytes that promotes skin homeostasis and suppresses atopic dermatitis inflammation.

The paper identifies critical base-resolution regulatory elements in immune gene expression using base editing and deep learning.