Xitiz Chamling

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

The paper identifies stage-specific miRNAs involved in human oligodendrocyte precursor cell differentiation and maturation through miRNA profiling of hESC-derived cells.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

This paper introduces a glial-enriched medium to increase astrocyte and oligodendrocyte populations in brain microphysiological systems without compromising neuronal differentiation.

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

The paper uses single-cell transcriptomics to analyze human oligodendrocyte progenitor cells, revealing transcriptional heterogeneity and pathways involved in their differentiation.

The paper shows thyroid hormone signaling controls the temporal switch between S and L/M cone fates in human retinal organoids.

The paper characterizes the transcriptome of human stem cell-derived retinal ganglion cells using single-cell RNA sequencing, identifying three subpopulations with varying maturity levels.

This paper develops an automated system for maintaining and differentiating human pluripotent stem cells, enabling large-scale culture and reducing variability.