Hai‐Quan Mao

This paper introduces a microfluidic platform for lipid nanoparticle formulation that improves scalability and efficiency in mRNA delivery.

This paper introduces NanoSTAMP, a spatially resolved in vivo screening platform for barcoded LNPs, linking formulation to cell-type uptake and tissue responses.

FALCON optimizes lipid nanoparticles for cell-selective mRNA delivery, improving transfection efficiency and selectivity in vivo.

This study identifies fibroblast-macrophage signaling as critical for biomaterial-induced tissue remodeling, revealing prolonged inflammation and novel cell types involved.

This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.

This study quantitatively investigates how different nanoplastics associate with and affect diverse cell types, revealing cell-type-dependent impacts on proliferation and motility.

This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.

This study identifies the causes of payload heterogeneity in lipid nanoparticles and proposes methods to improve RNA distribution uniformity.

This paper develops a method to create high-concentration, shelf-stable DNA transfection particles for AAV production, achieving tenfold higher pDNA concentration and reduced dosing volume.

This study shows that mRNA lipid nanoparticles (LNPs) can be tailored to traffic to specific organs, enhancing tissue-specific T cell responses and vaccine efficacy.

The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.

This study uses machine learning to identify LNP composition parameters that enhance transfection efficiency across cell types and modulate cell type-preferentiality.

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

The paper uses single-cell transcriptomics to analyze human oligodendrocyte progenitor cells, revealing transcriptional heterogeneity and pathways involved in their differentiation.