Author

Fraser Cunningham

University of DundeeORCID 0000-0001-6436-7555Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

David W. GrayiD· 3 shared Ian Hugh GilbertiD· 2 shared Amber Y. Sefton· 1 shared Andrew M. EdwardsiD· 1 shared Andrew PlateriD· 1 shared Barbara Forte· 1 shared Beatriz BaragañaiD· 1 shared Catrina Kerr· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

David W. GrayORCID

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Author profile →

3 papers

Recent·Most cited

BiochemistrySLAS TECHNOLOGYPeer-reviewedMar 13, 2026

Experience from an HTS campaign: Investigation of susceptibility and rescue of SARS-CoV-2 nsp3 protease assay from metal contamination

Irene Georgiou, Sandra O’Neill, Colin Robinson…·Duncan E. Scott

The paper investigates false positives in SARS-CoV-2 nsp3 protease HTS assays caused by metal contamination and identifies copper and palladium as primary contaminants.

DOI 10.1016/j.slast.2026.100409

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiochemistrybioRxivPreprintAug 19, 2025

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

Janine L. Gray, Elizabeth V. K. Ledger, Tiffany Suwatthee…·Edward W. Tate

The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.

DOI 10.1101/2025.08.19.671038

humanstructural biology

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintSep 5, 2023

The Quest to Identify USP8 Inhibitors for Parkinsons Disease, a PAINful Experience.

Stuart Lang, Fiona Bellany, De Lin…·Fraser Cunningham

The paper identifies PAINS in a USP8 inhibitor screening campaign for Parkinson's disease and discusses interference mechanisms affecting assay reliability.

DOI 10.1101/2023.09.05.556294

experimental assaydrug response / drug discovery

𝕏 PostBluesky