Eduard Sabidó

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

The paper profiles histone post-translational modifications across eukaryotic lineages to assess conservation of chromatin states, finding conserved euchromatin states but diverse repressive heterochromatin configurations.

The paper benchmarks cross-platform RNA modification quantification using LC-MS/MS and finds that harmonized workflows and SILIS normalization improve reproducibility across different instrument types.

The paper investigates genomic mechanisms underlying independent transitions to terrestrial life across species, finding lineage-specific gene changes that converge functionally.

The paper generates a benchmark dataset to evaluate proteomics instruments and workflows using high-throughput LC gradients across multiple platforms and organisms.

iDeepLC improves retention time prediction for peptides with unseen modifications by incorporating chemical structural information, outperforming previous models.

ProteoBench provides a centralized platform for comparing proteomics data analysis workflows, enabling benchmarking and community collaboration.

This study evaluates a commercial plasma enrichment strategy for improving low-abundance protein detection in human CSF, showing enhanced identification and coverage with high reproducibility.

The paper introduces TMTCal, a TMT-based multipoint internal calibration method for proteomics, demonstrating its application in quantifying proteome changes in ovarian cancer cells under cisplatin treatment.

This study identifies SMARCAD1 and TOPBP1 as regulators of heterochromatin maintenance during the transition from 2C-like to pluripotent states in mouse embryos.

This study shows that peroxiredoxin Tsa1 in yeast peroxiredoxinylates hundreds of proteins, affecting metabolism and stress resistance, with thioredoxins removing the resulting disulfide bonds.

This study identifies gene gain and regulatory shifts in terrestrial planarians as key mechanisms for terrestrialization, showing distinct stress response toolkits compared to freshwater relatives.

This study compares toxin and mucus protein evolution in aquatic and terrestrial flatworms, finding broader toxin gene repertoires and distinct functional expansions in terrestrial species.

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

This study identifies proteomic subtypes and recurrence patterns in IDH-wildtype glioblastoma using tissue and serum samples, revealing prognostic markers and proteomic plasticity in recurrent tumors.

This study investigates the role of RPL3L in ribosome heterogeneity and mitochondrial activity in cardiomyocytes, finding that its depletion increases ribosome-mitochondria interactions and ATP levels.

The paper identifies molecular changes in immunity postnatal in ELGANs with fetal inflammatory response, showing innate immune activation and adaptive immunity impairment.

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.