Alejandro Vaquero

This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.

This study identifies NUCKS1 as a novel SIRT7 interactor that promotes chromatin binding during senescence and liver aging, leading to metabolic and inflammatory gene expression.

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.