Gregory D. Fairn

This study identifies a minimal functional ZDHHC5 region required for NOD2 membrane recruitment and S-acylation, distinguishing requirements for substrate association, catalytic activity, and accessory-protein interactions.

This study identifies PTP1B's role in suppressing superoxide production during phagocytosis by inhibiting the SFK-Syk-Shc1-NOX2 signaling pathway at ER-PM membrane contact sites.

This study identifies S-palmitoylation as a reversible regulatory mechanism for GDH, affecting its quaternary structure and enzymatic activity through cysteine modifications.

This study identifies APT1/LYPLA1 as a context-dependent vulnerability in triple-negative breast cancer by showing its role in regulating cell proliferation through de-S-acylation of cell-cycle and mitochondrial proteins.

This study identifies ABHD17 isoforms as deacylases of NOD2, showing that inhibiting them enhances NOD2 membrane localization and function in Crohn's disease-associated variants.

The paper shows that cholesterol depletion from the phagocytic cup during exocytosis displaces Lyn kinase, reducing phosphotyrosine signaling and regulating phagocytic signaling.