Stef Jacobs

The paper uses deep mutational scanning to analyze resistance mutations in Fks1, revealing distinct resistance landscapes for echinocandins and triterpenoids, including a novel triterpenoid-specific hotspot.

The paper investigates how Erg3 loss-of-function contributes to echinocandin resistance in Candida species by analyzing combined mutations in ERG3 and FKS2.

This paper identifies the riboflavin biosynthetic pathway as a novel antifungal target in Candida species, showing that key enzymes are essential and that riboflavin uptake mechanisms differ among species.