Hans Carolus

The paper uses deep mutational scanning to analyze resistance mutations in Fks1, revealing distinct resistance landscapes for echinocandins and triterpenoids, including a novel triterpenoid-specific hotspot.

The paper investigates how Erg3 loss-of-function contributes to echinocandin resistance in Candida species by analyzing combined mutations in ERG3 and FKS2.

The paper identifies hyper-multidrug-resistant Nakaseomyces glabratus strains with fitness trade-offs and explores nitroxoline as a potential alternative therapy for resistant UTIs.

This study compares four CRISPR-Cas9 systems for genome editing in Candida auris, finding significant differences in efficiency and integration patterns.

This study compares sphingolipid profiles of fluconazole-resistant Candidozyma auris isolates to identify intra-clade lipid compositional differences linked to antifungal resistance.

The paper identifies Als5 and Scf1 as complementary adhesins in Candida auris that promote cell-cell interaction and biofilm formation through functional redundancy.