Ann Dean

This study shows that LDB1 is essential for maintaining pluripotency and supporting differentiation, particularly in erythroblasts, through effects on gene expression and chromatin structure.

The paper identifies Myrlin, an enhancer RNA that recruits MLL1 to regulate Myb transcription during erythroid differentiation.

The paper shows that mRNA from a super enhancer can regulate neighboring genes and TAD interactions by affecting chromatin modifications and enhancer activity.

The paper shows that the LDB1 complex uses CTCF to create specific long-range enhancer interactions in erythroid cells, activating genes like Car2.