Keith A. Breau

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study shows SOX9 elongates G1 phase in intestinal stem cells, enhancing injury resistance and stemness, and identifies the INK4A-Rb pathway as a mediator.

The paper develops a mathematical model of the PCP complex and validates its predictions using a human intestinal stem cell system to study feedback regulation during planar cell polarity.

This study shows that deleting estrogen receptor alpha in colonic epithelial cells protects female mice from inflammation but causes hyper-proliferation in males.

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

The paper compares methods for quantifying GFPuv yield in E. coli bioreactors, identifying optimal harvest times and highlighting the strengths of imaging over other techniques.

This paper develops an efficient electroporation method for transgenesis and gene editing in human intestinal stem cells, achieving high efficiency and viability.