Leonardo F. Ferreira

This study compares proteomic changes in IDS-KO mice treated with IV and adjunct nebulized Idursulfase, finding that nebulization enhances cardiac proteome adaptations.

This study evaluates nebulized and intravenous enzyme replacement therapy in mice with mucopolysaccharidosis type II, finding that combination treatment improves liver enzyme activity and disease features but not lung enzyme activity.

This paper develops a 6-minute limb function test for preclinical hindlimb ischemia models to assess muscular performance and hemodynamics, showing it detects therapeutic differences better than traditional measures.

This study shows chronic AHR activation in muscle worsens ischemic damage in CKD and PAD by impairing muscle function and mitochondrial health.