Author
Byung Hak Ha
Harvard UniversityORCID 0000-0001-6594-0835Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 29 mutual co-author links5 papers
Recent·Most cited
- BiochemistrybioRxivPreprint
RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor
Sayan Chakraborty, Jie Jiang, Javier Viñals…·Michael J. Eck
The paper investigates MEK inhibitor selectivity across RAF isoforms and develops a covalent ARAF-MEK inhibitor with improved potency.
- BiochemistrybioRxivPreprint
In vitro reconstitutions suggest a general model for paradoxical activation of ARAF, BRAF, and CRAF by diverse RAF inhibitor types that does not rely on negative allostery.
Emre Tkacik, Dong Man Jang, Kayla Boxer…·Michael J. Eck
This study shows that RAF inhibitors paradoxically activate ARAF, BRAF, and CRAF through dimerization, not negative allostery, by using biochemical assays and mass photometry.
DOI 10.64898/2025.12.15.694443 - BiochemistryProtein and Peptide LettersPeer-reviewed
Nickel binding to c-Src SH3 domain facilitates crystallization
Xander Calicdan, Oriana S. Fisher, Byung Hak Ha…·Amy L. Stiegler
This paper reports a unique crystal structure of the c-Src SH3 domain mediated by nickel ions, revealing a 2:2 stoichiometry and dimerization mechanism.
DOI 10.2174/0109298665417324250929120040 - BiochemistrybioRxivPreprint
Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF complexes
Emre Tkacik, Dong Man Jang, Kayla Boxer…·Michael J. Eck
This study compares the potency of thirteen RAF inhibitors against ARAF, BRAF, and CRAF isoforms, revealing differences in inhibitor selectivity and mechanism.