PhysiologyScience SignalingPeer-reviewed
Purinergic P2Y2 Receptor-Induced Activation of Endothelial TRPV4 Channels Mediates Lung Ischemia-Reperfusion Injury
Maniselvan Kuppusamy, Huy Q. Ta, Hannah N. Davenport…·Swapnil K. Sonkusare
This study identifies the purinergic P2Y2 receptor as a mediator of lung ischemia-reperfusion injury by activating endothelial TRPV4 channels through extracellular ATP release via Panx1.