M Suchan

The paper introduces k4neo, a tool that computes tumor specificity of transcript variants by k-mer indexing of healthy tissue RNA-seq data, identifying tumor-specific antigens across multiple cancer cohorts.

This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.

The paper shows that long-lasting mRNA-encoded IL2 restores immune responses in MHC class I-deficient cancers by activating neoantigen-specific CD8+ T cells.

This paper introduces splice2neo, a tool to identify tumor-specific splice junctions from somatic mutations, which can generate neoantigen candidates for immunotherapy.