Joseph Aloysius Ludwig

This study identifies DSRCT-specific neogenes regulated by the EWS::WT1 fusion protein and shows their potential as biomarkers and therapeutic targets in desmoplastic small round cell tumors.

This study uses single-nucleus multiome sequencing and spatial transcriptomics to analyze liposarcoma subtypes, revealing distinct cellular states, immune features, and gene regulatory circuits.

The paper maps the differentiation landscape of osteosarcoma using single-cell data to identify gene modules linked to cell fate and patient survival.

The paper shows enzalutamide reduces DSRCT growth independently of AR, challenging the hypothesis that AR drives male predominance in this cancer.