Jyothishmathi Swaminathan

This study identifies the REST-AKT-SOX2 axis as a key regulator of stem/progenitor identity and Midkine-mediated communication in SHH medulloblastoma, highlighting it as a potential therapeutic target.

The paper shows that REST elevation in cerebellar granule cell progenitors increases chromatin accessibility, alters Grk6 transcript expression, and hyperactivates Cxcr4-Sdf1 signaling, leading to increased cell migration.

The paper maps the differentiation landscape of osteosarcoma using single-cell data to identify gene modules linked to cell fate and patient survival.

EpiSAFARI detects valleys in epigenetic signals to improve functional element annotations, showing high conservation and enrichment in regulatory regions.