Author

Sylwia D. Tyrkalska

Instituto de Salud Carlos IIIORCID 0000-0001-6654-0163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Víctoriano MuleroiD· 4 shared Diana García‐MorenoiD· 3 shared Juan M. Lozano GiliD· 2 shared Mai Nguyen ChiiD· 2 shared Alicia Martínez‐LópeziD· 1 shared Ana B. ArroyoiD· 1 shared Andrés JereziD· 1 shared Annamaria PedotoiD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

Víctoriano MuleroORCID

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4 papers

Recent·Most cited

ImmunologyFEBS JournalPeer-reviewedNov 28, 2025

Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins

Liz Hernández, Théo Paris, Maria Demou…·Laure Yatime

The paper characterizes two teleost-specific S100 proteins, S100i1 and S100i2, showing they share structural, functional, and expression features with mammalian S100 proteins.

1 citation

zebrafishproteomics

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ImmunologybioRxivPreprintFeb 20, 2025

Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia Syndrome

Juan M. Lozano Gil, Lola Rodríguez‐Ruiz, Manuel Palacios…·Víctoriano Mulero

This study shows that tyrosine kinase inhibitors can restore erythropoiesis in Diamond-Blackfan Anemia by inhibiting NLRP1 inflammasome activation.

1 citation

humanzebrafish

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ImmunologybioRxivPreprintJan 22, 2025

Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition

Annamaria Pedoto, Juan M. Lozano Gil, Mai Nguyen Chi…·Víctoriano Mulero

This study shows macrophage inflammasomes drive anti-inflammatory responses by transferring neutrophil-derived ASC specks and inhibiting caspase-1 via Gasdermin E.

1 citation

zebrafishexperimental assay

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ImmunologyCell Death DiscoveryPeer-reviewedAug 29, 2024

Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation

Ana B. Arroyo, Sylwia D. Tyrkalska, Eva Bastida‐Martínez…·Víctoriano Mulero

This study shows that Peds1 deficiency in zebrafish causes myeloid cell apoptosis and worsened inflammation, with plasmalogen supplementation improving outcomes.

12 citations

zebrafishexperimental assay

𝕏 PostBluesky