Joshua A. Manuel

This study examines how sub-inhibitory antibiotic concentrations affect mutation rates and persistence in Staphylococcus aureus, showing increased mutation rates and reduced persistence.

This study shows that long-term exposure to bacteriostatic antibiotics in E. coli leads to the emergence of small colony variants (SCVs) that confer heteroresistance, which reverts upon antibiotic removal.

This paper develops two mathematical models of heteroresistance to explore how resistance ascends and reverts during antibiotic treatment, showing that current identification methods are insufficient.