Amaia Vilas‐Zornoza

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

This study identifies novel RAB13+ endothelial and profibrotic mesenchymal cells in aged human bone marrow using single-cell RNA sequencing and spatial transcriptomics.

The paper identifies molecular dynamics and a new marker, Aspn, for reparative cardiac fibroblasts in mice, pigs, and patients after myocardial infarction.

This study maps epigenetic and transcriptional changes in myeloma progression from precursor to advanced stages, identifying key transcription factors involved in disease development.

This study uses scRNA-seq to analyze del(5q) MDS patients, revealing shared and unique transcriptional alterations and lenalidomide's impact on disease and treatment response.

This study shows gene therapy can restore the transcriptional program of hematopoietic stem cells in Fanconi Anemia patients, making them resemble healthy donor cells.

This study uses single-cell RNA sequencing to analyze changes in hematopoietic stem and progenitor cells during aging and myeloid malignancies, identifying altered gene expression and regulatory networks.

scMomentum infers cell-type-specific regulatory networks and energy landscapes from single-cell transcriptomic data without needing temporal or perturbation experiments.