Arushi Lahiri

The paper identifies recurrent acquisition of nuclease-protease pairs in bacterial antiviral immunity and shows their proteolytic activation mechanism across different immune systems.

The paper shows that the CRISPR-related enzyme mCpol produces cyclic oligonucleotides to prevent cell death and counteract viral immune evasion.

The paper develops a CRISPRi-ART system to knock down protein expression in diverse bacteriophages and identifies essential genes, including many with unknown functions.

This study identifies Hachiman as a bacterial antiphage defense system that degrades all DNA in response to DNA damage, revealing its role as a genome integrity sensor.

The paper traces the evolutionary origin of eukaryotic RNA-guided endonucleases, showing they evolved from a specific clade of bacterial IS607 TnpB enzymes.