Author
Innovative Genomics InstituteORCID 0000-0002-0348-6910Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Owen T. Tuck, Jason J. Hu, Santiago C. Lopez…·Jennifer A. Doudna
The paper identifies recurrent acquisition of nuclease-protease pairs in bacterial antiviral immunity and shows their proteolytic activation mechanism across different immune systems.
Allison K. Guitor, Shuai Wang, Owen T. Tuck…·Jillian F. Banfield
The paper identifies megaplasmids in Enterobacteriaceae species, showing they are self-transmissible, encode drug resistance, and may enhance bacterial competitiveness.
Katarzyna M. Soczek, Joshua C. Cofsky, Owen T. Tuck…·Jennifer A. Doudna
The paper shows CRISPR-Cas12a bends DNA to destabilize base pairs during target recognition, similar to CRISPR-Cas9 but with different hybridization directionality.
Owen T. Tuck, Benjamin A. Adler, Emily G. Armbruster…·Jennifer A. Doudna
This study identifies Hachiman as a bacterial antiphage defense system that degrades all DNA in response to DNA damage, revealing its role as a genome integrity sensor.
Amy R. Eggers, Kai Chen, Katarzyna M. Soczek…·Jennifer A. Doudna
The paper shows that engineered GeoCas9 variants enhance genome editing by accelerating DNA unwinding, revealing a new role for the WED domain in this process.