Emily G. Armbruster

The paper shows that VIPR systems in E. coli mediate competition between phages and their satellite counterparts, with satellites using decoy RNAs to counteract repression.

This study identifies Rhc as a multifunctional protein essential for DNA replication and transcription in nucleus-forming phages, revealing its role in resolving R-loops and coordinating gene expression.

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

The paper shows that the CRISPR-related enzyme mCpol produces cyclic oligonucleotides to prevent cell death and counteract viral immune evasion.

The paper shows that MdfA and ClpCP protease regulate metabolic differentiation in Bacillus subtilis sporulation by depleting metabolic enzymes in the forespore.

The paper develops a CRISPRi-ART system to knock down protein expression in diverse bacteriophages and identifies essential genes, including many with unknown functions.

The paper identifies gp335, a phage protein from Churi, which inhibits Pseudomonas aeruginosa growth by interfering with protein translation through ribosome association.

This study identifies a bacterial NLR-related protein that detects phage infection through a conserved interface, triggering programmed cell death to limit viral spread.

This study identifies Hachiman as a bacterial antiphage defense system that degrades all DNA in response to DNA damage, revealing its role as a genome integrity sensor.

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.