Liheng Yang

This study shows that Toxoplasma gondii infection redirects placental trophoblast lineage specification, promoting infection-permissive cells over infection-resistant ones.

This study uses single-nucleus RNA sequencing and organoids to identify unique placental cell types and immune adaptations in Jamaican fruit bats, revealing species-specific gene programs and attenuated antiviral responses in trophoblasts.

This study compares rhesus macaque and human placental organoids to identify evolutionary differences in trophoblast gene expression and differentiation pathways.

This study uses spatial transcriptomics and organoids to define cellular diversity at the swine maternal-fetal interface, revealing conserved trophoblast populations and novel markers.

The paper identifies DUX4-stimulated genes as an antiviral defense program in human trophoblasts, specifically targeting herpesviruses through an alternative pathway to the IFN response.

The paper compares trophoblast differentiation in fetal membranes and chorionic villi using organoids and RNA sequencing, finding region-specific gene expression patterns influenced by environmental cues.

This study compares syncytiotrophoblast gene expression in placental tissue and trophoblast organoids using snRNA-seq, identifying distinct nuclear subtypes and environmental influences on STB gene expression.

This study uses human trophoblast stem cells to model placental resistance to Toxoplasma gondii and Listeria monocytogenes, showing that syncytiotrophoblasts are more resistant than cytotrophoblasts.