ImmunologyCancer DiscoveryPeer-reviewed
EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
Alexandra Kuhlmann-Hogan, Thekla Cordes, Ziyan Zoe Xu…·Susan M. Kaech
This study shows EGFR-mutant lung adenocarcinomas exploit alveolar macrophage metabolism via GM-CSF--PPARγ signaling to support tumor growth and EGFR signaling, suggesting new therapeutic strategies combining statins and PPARγ inhibition.
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