Thekla Cordes

This study shows human macrophages take up extracellular citrate but do not use it as a carbon source, instead modulating glutamine metabolism and immune responses during infection.

This study shows that extracellular substrate composition affects macrophage immunometabolism, with citrate modulating immune responses and SLC13A3 expression.

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

The paper identifies 2-hydroxymethylsuccinate as a product of itaconate metabolism via a CoA-independent pathway and shows tissue-specific degradation routes.

This study uses mass spectrometry and in vivo 13C tracing to show itaconate is rapidly cleared from plasma, excreted in urine, and metabolized in the liver and kidneys.

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

The paper develops a method to screen oncogenic genes across multiple lineages using teratomas and identifies drivers of proliferation in specific cell types.