ImmunologyeLifePeer-reviewed
Structure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development
Pramila Rijal, Leiyan Wei, Guido C. Paesen…·Alain Townsend
This paper improves the expression and stability of influenza neuraminidase by grafting antigenic loops from low-expressing variants onto high-expressing scaffolds, resulting in vaccine-effective hybrid proteins.