Author

Abigail Shea

Institute of Cancer ResearchORCID 0000-0001-7029-1745Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Alejandra BrunaiD· 3 shared Alejandro Allo AnidoiD· 2 shared Ayeh Sadat SadriD· 2 shared Birgit GeoergeriD· 2 shared Cecilia RouxiD· 2 shared Christie English· 2 shared Emilia CheniD· 2 shared Gudrun SchleiermacheriD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Alejandra BrunaORCID

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3 papers

Recent·Most cited

BioinformaticsBioinformaticsPeer-reviewedSep 27, 2026

Serval: A modular framework for decoding imaging based spatial transcriptomics data

Jenkin Tsui, Naila Adam, Woongcheol Choi…·Nicholas A. Walton

Serval is a modular framework for decoding spatial transcriptomics data that introduces Cosine, a method improving transcript recovery and correlation with expression references.

DOI 10.1093/bioinformatics/btag707

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 13, 2025

AP-1 Primes Transcriptional Noise-Led Cancer Treatment Adaptation Through KDM5 Chromatin Rewiring

Alejandro Allo Anido, Cecilia Roux, Ayeh Sadat Sadr…·Alejandra Bruna

The paper identifies transcriptional noise as a driver of cancer treatment adaptation through AP-1 and KDM5-mediated chromatin rewiring in neuroblastoma and hepatoblastoma.

DOI 10.1101/2025.10.13.682004

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 7, 2023

Environment-Dependent Modes of Adaptive Evolution in Neuroblastoma: Plasticity as a Selectable Trait

Cecilia Roux, Siân Hamer, Abigail Shea…·Alejandra Bruna

This study identifies three modes of plasticity in neuroblastoma that shape tumour evolution under selective pressures and therapy resistance.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky