Siân Hamer

This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.

The paper identifies transcriptional noise as a driver of cancer treatment adaptation through AP-1 and KDM5-mediated chromatin rewiring in neuroblastoma and hepatoblastoma.

This study uses single-cell multiomics to trace clonal and phenotypic dynamics in hepatoblastoma after cisplatin treatment, identifying a plasticity-proliferation axis driven by BIRC5.

This study identifies three modes of plasticity in neuroblastoma that shape tumour evolution under selective pressures and therapy resistance.