Ondřej Kuda

The paper identifies that OXPHOS-deficient cells sequester polyunsaturated fatty acids into triacylglycerols to protect against ferroptosis, observed in patient fibroblasts and hypoxia conditions.

This study investigates how exercise affects insulin sensitivity and FAHFA levels in obese mice, finding that chronic exercise improves insulin sensitivity in wild-type mice but not in ADTRP KO mice.

This study shows that DGAT-mediated lipid droplet biogenesis regulates ferroptosis by modulating lipid distribution and membrane unsaturation, with context-dependent effects in different cancer cell types.

This study examines sex differences in FAHFA metabolism across tissues in mice, finding higher FAHFA levels in females in specific adipose depots and lower Adtrp expression, suggesting sex-dependent regulation of FAHFA metabolism.

LORA analyzes lipidomic data to identify overrepresented lipids using standardized nomenclature and hierarchical structure, providing insights into molecular composition.