Alexander Andreas Navarini

The paper shows MITF promotes melanoma survival by increasing resistance to reactive oxygen species through regulating antioxidant genes like IDH1 and NNT.

The paper identifies MPO mutations as genetic determinants of pustular skin disease and increased neutrophil counts through exome sequencing and UK Biobank analysis.

This paper develops a machine learning classifier to predict whether missense variants cause gain or loss of protein function, achieving high accuracy on independent data.