H. Llewelyn Roderick

This study shows that SMIT1 promotes cardiac hypertrophy and fibrosis in mice under pressure overload by enhancing IP3/Ca2+-dependent signaling pathways.

The paper identifies MGST1 as a key antioxidant gene in cardiac fibroblasts, showing its loss in heart failure increases oxidative stress and ferroptosis susceptibility.

This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.

The paper develops a 3D-printed targeted sampling method to accurately identify and study arrhythmogenic sites in the mammalian heart after myocardial infarction.

This study shows that Bcl-2 knockout in hiPSCs delays cardiomyocyte differentiation and reduces c-Myc expression, but not functionality in active areas.

The paper shows that MSK-mediated phosphorylation of histone H3 at serine 28 couples MAPK signaling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses.