Pandurangan Vijayanand

This study identifies a ubiquitous neoantigen-reactive T-cell response across multiple metastatic sites in a patient with pancreatic neuroendocrine tumor, supporting the use of mutation-sharing status for neoantigen selection in immunotherapy.

This study characterizes the phenotypic and functional diversity of neoantigen-specific CD4+ T cell responses to a growing tumor and shows how immunotherapy alters their composition and efficacy.

The paper introduces a method to study cell-cell interactions at single-cell resolution, revealing unique transcriptomic signatures in T cell-monocyte complexes during TB and dengue infection.

This study examines T cell and antibody responses in vaccinated individuals over three years, finding stable T cell responses and increased regulatory T cells after multiple boosters.

This paper identifies IFN-driven cross-talk between immune cell types in SLE using gene expression analysis and a novel integrative method.

This study analyzes single-cell transcriptomes of SARS-CoV-2-reactive CD8+ T cells from COVID-19 patients and healthy controls, revealing differences in functional properties between mild and severe cases.

FitHiChIP identifies significant chromatin contacts from HiChIP data by modeling coverage and distance scaling, validating enhancer interactions, and enabling differential contact analysis between immune cell types.

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.