Johannes Schöneberg

The paper presents a framework for whole-cell digital twin simulations using 4D lattice light-sheet microscopy data and particle-based reaction-diffusion modeling to accurately reproduce mitochondrial dynamics.

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

The paper introduces far-red chemigenetic kinase activity biosensors enabling five-color multiplexing, 4D imaging, and super-resolution via STED microscopy.

This study quantifies 4D mitochondrial networks in human organoids during development, identifying distinct phenotypes linked to cell type and age.

This paper introduces WH-Transform, a GPU-accelerated algorithm for real-time preprocessing of tilted light-sheet microscopy data, enabling fast visualization and analysis of large datasets.

This study shows that engineered nanotopographies create temporary nuclear membrane openings, enabling molecular exchange without cell penetration.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

This study introduces MitoSpace, a self-supervised deep learning approach to map drug-induced mitochondrial phenotypes, revealing a more complex morphology landscape than previously thought.