Hiroyuki Hakozaki

The paper presents a framework for whole-cell digital twin simulations using 4D lattice light-sheet microscopy data and particle-based reaction-diffusion modeling to accurately reproduce mitochondrial dynamics.

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

The paper introduces far-red chemigenetic kinase activity biosensors enabling five-color multiplexing, 4D imaging, and super-resolution via STED microscopy.

This study quantifies 4D mitochondrial networks in human organoids during development, identifying distinct phenotypes linked to cell type and age.

This paper introduces WH-Transform, a GPU-accelerated algorithm for real-time preprocessing of tilted light-sheet microscopy data, enabling fast visualization and analysis of large datasets.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

This study introduces MitoSpace, a self-supervised deep learning approach to map drug-induced mitochondrial phenotypes, revealing a more complex morphology landscape than previously thought.