Author

Linxuan Hao

Washington University in St. LouisORCID 0000-0001-7127-5210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Assay:structural biology· 1

Frequent Co-Authors

Timothy M. LohmaniD· 2 shared Kacey N. MerschiD· 1 shared Nicole T. FazioiD· 1 shared Rui ZhangiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBiophysics

Timothy M. LohmanORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 11, 2025

The Nuclease Domain of E. coli RecBCD Regulates DNA Binding and Base Pair Melting

Linxuan Hao, Rui Zhang, Timothy M. Lohman

This study shows that the RecB nuclease domain in E. coli RecBCD regulates DNA binding and base pair melting through allosteric effects and linker interactions.

DOI 10.1101/2025.07.11.664400

E. colistructural biology

𝕏 PostBluesky

BiophysicsJournal of Molecular BiologyPeer-reviewedOct 17, 2023

E. coli RecBCD Nuclease Domain Regulates Helicase Activity but not Single Stranded DNA Translocase Activity

Nicole T. Fazio, Kacey N. Mersch, Linxuan Hao, Timothy M. Lohman

This study shows that the nuclease domain of E. coli RecBCD affects dsDNA unwinding rates but not ssDNA translocation, suggesting the nuclease domain influences base pair melting rather than translocation.

5 citations

E. coliexperimental assay

𝕏 PostBluesky