MicrobiologyPLoS BiologyPeer-reviewed
Multiple layers of innate immune response antagonism of SARS-CoV-2
Fuchun Zhou, Sivakumar Periasamy, Nathaniel D. Jackson…·Alexander A. Bukreyev
This study generates twelve SARS-CoV-2 viruses with mutations in individual proteins and shows that many have interferon-antagonizing activity and immunosuppressive effects in human cells and mice, with NSP1 and NSP15 having the greatest impact.