George Khelashvili

This study investigates the structure and function of human Xkr4, showing it scrambles lipids and adopts a novel conformation that promotes membrane thinning, essential for phosphatidylserine externalization.

This paper investigates how C-terminal domains of GPCRs interact with membranes to regulate receptor function, showing that these interactions influence transducer coupling and are modulated by phosphorylation and membrane composition.

This paper develops and applies LDA-based methods to identify optimal collective variables from MD simulations of the MFSD2A transporter, improving the classification of metastable states.

The paper shows cholesterol inhibits GPCR-mediated phospholipid scrambling in synthetic vesicles, suggesting a mechanism for maintaining plasma membrane asymmetry.