Cell BiologybioRxivPreprint
Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2
Marina Schrecker, Yeeun Son, Rosa Planells‐Cases…·Richard K. Hite
This study identifies TMEM9 and PI(3,5)P2 as regulators of ClC-3 activity through cryo-EM structures showing TMEM9 blocks Cl- ion flow and PI(3,5)P2 stabilizes their interaction.