Author

Adhish S. Walvekar

Institute for Stem Cell Biology and Regenerative MedicineORCID 0000-0001-7344-7653Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:metabolomics· 2 Approach:statistical model· 2 Organism:yeast· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Sunil LaxmaniD· 3 shared Rajalakshmi SrinivasaniD· 2 shared Ritu GuptaiD· 2 shared Zeenat RashidaiD· 2 shared Aswin Sai Narain SeshasayeeiD· 1 shared Premal ShahiD· 1 shared Shun Liang· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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3 shared papersSystems Biology

Sunil LaxmanORCID

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3 papers

Recent·Most cited

Systems BiologyPLoS GeneticsPeer-reviewedDec 30, 2020

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program

Rajalakshmi Srinivasan, Adhish S. Walvekar, Zeenat Rashida…·Sunil Laxman

The paper shows Gcn4/ATF4 regulates metabolic precursor biosynthesis and translation capacity in yeast growth programs, balancing metabolic supply with translation output.

11 citations

yeastChIP-seq

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BiochemistrybioRxivPreprintDec 28, 2018

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis, to couple metabolism to cell cycle progression.

Ritu Gupta, Adhish Walvekar, Shun Liang…·Sunil Laxman

The paper shows tRNA U34-thiolation regulates phosphate homeostasis, linking carbon and nitrogen metabolism to cell cycle progression by controlling metabolic flux and phosphate availability.

DOI 10.1101/507707

metabolomicsexperimental assay

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Systems BiologyMolecular Biology of the CellPeer-reviewedOct 24, 2018

Methionine coordinates a hierarchically organized anabolic program enabling proliferation.

Adhish S. Walvekar, Rajalakshmi Srinivasan, Ritu Gupta, Sunil Laxman

The paper identifies how methionine reprograms yeast metabolism to support proliferation by rewiring key metabolic pathways and co-opting a stress response regulator.

50 citations

yeastmetabolomics

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