Ritu Gupta

This study shows Rad53/Chk2 links mitochondrial function and ROS levels to G2/M cell cycle progression in yeast.

This study identifies ABCF3 as the mammalian ortholog of yeast Gcn20, which is recruited to ribosomes during amino acid starvation and interacts with GCN1 to activate Gcn2.

The paper shows cells prioritize restoring amino acids based on demand and biosynthetic cost, with arginine being the highest priority.

The paper shows tRNA U34-thiolation regulates phosphate homeostasis, linking carbon and nitrogen metabolism to cell cycle progression by controlling metabolic flux and phosphate availability.

The paper identifies how methionine reprograms yeast metabolism to support proliferation by rewiring key metabolic pathways and co-opting a stress response regulator.